Monday, October 10, 2011
Sunday, October 9, 2011
Fwd: Molecular Genetic Pathology, 1st ed. 2008
via e-Pathology by Dr. PaCiFiC on 10/9/11
Molecular Genetic Pathology, 2008
Liang Cheng, David Y. Zhang
ISBN-10: 1588299740
ISBN-13: 9781588299741,
Molecular Genetic Pathology presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Part I examines the clinical areas of molecular biology, genomics, pharmacogenomics and proteomics, while Part II covers the molecular areas of medical genetics, microbiology, hematology, transfusion medicine, oncology and forensic pathology. The volume provides a unique reference for the practicing pathologist and medical geneticist as well as a review book for residents and fellows in training in pathology, medical genetics and molecular genetic pathology.
dOWNLOAd .
LIPPINCOTT BIOCHEMISTRY 4TH EDITION
via all the free books for medical student,for usmle p by punjabisher_rules on 9/28/11
LINK 1-http://adf.ly/2wM7Z
LINK 2-http://adf.ly/2wMCd
Angelman Syndrome vs. Prader Willi Syndrome: Genetics and Clinical Features
via Score 99 USMLE blog by info@pedsquiz.com (Sun) on 10/8/11
Prader-Willi and Angelman syndromes are the two most common genetic disorders of imprinting. The concept of imprinting lies in the fact that the function of certain genes is dependent on their parents: maternal or paternal. Basically there is something wrong with the 15q11 region of the paternally derived chromosome in Prader Willi syndrome and that of the maternally derived chromosome in Angelman syndrome.
Prader-Willi phenotype can occur as a result of one of the following
1. Deletion of 15q11-q13 including the Prader-Willi critical region of the paternally derived chromosome 15 (most common)
2. Abnormality of the structure of Prader-Willi critical region of 15q11-q13 (for example translocation)
3. If the child has two maternally derived chromosome 15s. (Hence absence of paternal chromosome 15)
4. Mutations of imprinting control center genes (rare)
The critical region of chromosome 15 for Angelman syndrome is located very close to the Prader-Willi critical region. But, when deletion of the Angelman critical region results, it is the maternally derived chromosome that is affected.
Mechanisms leading to Angelman syndrome include the following:
1. Deletion of the 15q11-q13 including the Angelman critical region of the maternally derived chromosome 15 (most common)
2. Abnormality of the structure of the Angelman critical region of 15q11-q13 (e.g. translocation)
3. If the child has two paternally derived chromosome 15s. (Hence absence of maternal chromosome 15)
5. Mutations of the ubiquitin-protein ligase gene (UBE3A)
6. No identifiable etiologic mechanisms but a positive family history of other affected individuals and a classic phenotype
Clinical features of Prader Willi syndrome:
Newborns: hypotonia, poor sucking and swallowing, weak cry
Infancy: Delayed motor and speech development
Toddler: Hypotonia goes away! Extreme appetite leading to morbid obesity.
In addition hands and feet are noticeably small from birth, height is short and the penis and testes are hypoplastic. Patients have emotional lability and extreme temper tantrums.
Clinical features of Angelman syndrome:
Severe cognitive deficits; speech is heavily impared. Inappropriate paroxysms of laughter (happy puppets). Physical features include microcephaly, maxillary hypoplasia, large mouth, and short stature.Seizures are common. Except for case reports, all patients are infertile.
Wednesday, October 5, 2011
Shoulder Surgery: Principles and Procedures
via MEDICAL BOOKS FREE by admin on 10/3/11
This comprehensive, new guide clearly presents the principles of both normal and abnormal shoulder mechanics and shows clinicians how to successfully perform a variety of procedures. The authors focus on time-tested techniques and the basic tools every surgeon has at their disposal…instead of those that need special, complex, or expensive equipment. Over 1,400 superb original Click here to Download this Book Free
CLINICAL MICROBIOLOGY MADE RIDICULOUSLY SIMPLE
Fwd: Medical Ebooks Collection
via Medical - Download All You Want - HeroTurko.com by georgus on 10/5/11
Medical Ebooks Collection
English | 68 Books | PDF | Genre: Educational Ebooks, Medical Texts | 768 MB
English | 68 Books | PDF | Genre: Educational Ebooks, Medical Texts | 768 MB
68 medical books
Annotated Multiple Choice Questions: Australian Medical Council
via MEDICAL BOOKS FREE by admin on 10/3/11
The Australian Medical Council (AMC) has prepared this book to assist overseas-trained doctors who are preparing for the AMC AMCQ examination. This book will be a valuable guide and self-assessment tool to assist in sitting for this exam. It also illustrates the best-practice principles for a wide range of medical conditions found in the Australian Click here to Download this Book Free
Fwd: CD-ROM Complete Human Anatomy Primal 3D Interactive Series (9CDs)
via Medical - Download All You Want - HeroTurko.com by georgus on 10/5/11
CD-ROM Complete Human Anatomy Primal 3D Interactive Series (9CDs) | 5.76 GB
Professional interactive guide to the anatomy, designed specifically for medical professionals, as well as students and enthusiasts looking for more knowledge of users, which allows you to look into the most secluded corners of the human body.
Monday, October 3, 2011
Nobel winner died days before award announced
Sent to you by Anthony via Google Reader:
via ScienceRoll by berci.mesko@gmail.com (Bertalan Meskó) on 10/3/11
This is one of the saddest stories I've ever heard in science. Today,the Nobel Prize Committee awarded the Nobel Prize to Bruce A. Beutler (USA), Jules A. Hoffmann (France) "for their discoveries concerning the activation of innate immunity" and to Ralph M. Steinman (USA or Canada) "for his discovery of the dendritic cell and its role in adaptive immunity". Later today they found out Steinman died of pancreatic cancer last Friday. From the news:
The Nobel committee had been unaware of Ralph Steinman's death and it was unclear whether the prize would be rescinded because Nobel statutes don't allow posthumous awards.
Steinman, 68, who shared the prize with American Bruce Beutler and French scientist Jules Hoffmann, died on Sept. 30 of pancreatic cancer, acccording to Rockefeller University, which said he had been treated with immunotherapy based on his discovery of dendritic cells two decades earlier.
Things you can do from here:
- Subscribe to ScienceRoll using Google Reader
- Get started using Google Reader to easily keep up with all your favorite sites
Fwd: PURINE SYNTHESIS AND LESCH-NYHAN SYNDROME
via USMLE SUCCESS ACADEMY by Paul Ciurysek, MD on 10/3/11
Many students know the pathology of Lesch-Nyhan syndrome, most don't actually understand the underlying pathophysiology. The Step 1 exam loves to ask about the pathophysiology of this syndrome, so this video will ensure absolutely everything you might be asked about it is covered.
Enjoy!
If anybody has anything constructive to add to this, please do so in the comments section.
Dr. Paul
Subscribe to:
Posts (Atom)